Current clinical trends involve the use of plant based products as therapeutic agents in a wide range of applications. For years, plants are known to possess cytotoxicity against different cancer forms. The present study involved an attempt to explore the cytotoxicity potential of hydroalcoholic flower extract of Butea monosperma on Vero and RAW 264.7 cell line. Traditionally, the flower extract is well known for its antimicrobial, wound healing, antidiarrheal, hypoglycemic, hepatoprotective, antioxidant, anthelmintic, anticonvulsive, antistress, antiinflammatory activities. To determine in-vitro cytotoxicity of flower extract, different concentrations of crude extract were tested on the above cell lines by 3-(4,5-dimethyl thiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The extract showed a significant dose dependent cytotoxic effect against both the cell lines. At lowest concentration 15.625 µg/ml, 8.33% inhibition was exhibited and highest inhibition of 37.29% was observed at concentration 500 µg/ml, respectively in case of RAW 264.7 cells. Against Vero cell lines, the extract demonstrated minimum inhibition of 15.35% at 15.625 µg/ml concentration and maximum inhibition of 50.58% was displayed at 500 µg/ml. The study displayed that the Butea monosperma flower extract exhibited a great potential in exerting a cytotoxic effect on cell lines. The activity may be pronounced due to the presence of active components like chalcones and flavonoids.
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